Aisha seems to be the wife who is spoken of - as a child, she was initially betrothed to another man, but he was set aside when Aisha was suggested as a match for Mohammed, whose one wife had just died. Also, Mohammed and Aisha are said to have developed a true fondness for each other, and it is reported that he died with her, with his head in her lap.
http://en.wikipedia.org/wiki/Aisha
There were two other "co-wives"; many men mentioned in the Christian Old Testament (most notably) had many wives.
Different times, different cultures.
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