Antidepressants are really tough drugs; because everyone's brain chemistry is so different. I don't think it was fair for GSK to withhold negative trial data, but let's face it: drugs are very potent and affect everyone differently. That's why a lot of them are prescription.

As the medical world understands the chemistry part of depression, they'll be able to make "smarter" drugs with fewer side effects. Actually, this is true for all types of medication.