What meds is he on?
I don't know if this helps a thickened bladder wall, but a number of cats are put on amitryptiline to relax the bladder muscle. Maybe ask your vet if that would help Irwin?
I'm so sorry to hear how ill Irwin has been...hopefully he will even out in the next several days. I would guess his bladder is more sensitive than usual.
{{{hugs}}}
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