Cali, holistic breeders still take their dogs to the vets for
other tests.
(this was all new to me 9 years ago)
Sheba breeder did not believe in vacinating (accept
for rabies) and he used Nosodes.
After speaking to my vet, I decided against it,
and the breeder vacinated Sheba for me.
Now vacination protocal might change in the future,
where you do not need to vacinate yearly for certain
disease's such as distemper and Parvo.
Sheba will be 10, and I might no longer vaccinate her
accept for rabies.

But "reputable" breeders who do use holistic methods
study their dogs lines for genetics problems to pick
the perfect match before breeding.
They also go to the vets and get the required tests
done for known heriditary diseases known to that
breed. example: ( cerfs for the eyes) elbow and hip testing, or
even certain blood tests.
So just because a breeder doesn't believe in vacinating,
does not mean they do not still check for other diseases
in their breeds lines before breeding.