I would suggest the separate room also. It sounds like she wants your attention, but doesn't want the other cats there when she's getting it. When she wants the canned food, give that to in a separate room also. Try opening the can and giving everyone some, then taking her and her food into a separate room. Stay there while she eats it and then try playing with her.

I think some one on one attention where the others aren't able to intrude will probably bring about a different Louise.

Good luck and please let us know how things go.