Yes, a woman I know was a paranoid schizophrenic, and if she missed a dose of her medicines, she would sometimes decide the doctors or the medicines themselves were to blame, and then she would hide them, or refuse to take them, flush them, etc. It was sad, because when she was on the correct dosage, she was nice and sane and fairly pleasant. It is such a tricky disease, and our brain chemistry is fragile and often misunderstood.