The big caveat is that it is very difficult to migrate away from Thunderbird if you ever want to. So be sure to check that box "leave a copy on the server" if you use it.
X2 for Thunderbird. Another caveat is to make sure it does not set up as an IMAP account if your ISP supports POP accounts.
I didn't go for Thunderbird after all because I had some trouble installing, went for this one instead http://www.emclient.com/?lang=en. It's working fine, so far.
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