Moosmom, I am so sorry you had a negative experience with amitryptiline. I have had the exact opposite happen with Ming, he no longer fights with Mac, and he become even more of a super love cat than he was before. My vet said this med has different reactions with different cats. She said 60% of cats do very well on it, but for the other 40%, it is just as you described. I believe that this med has saved Ming's life, because he had chronic blockages and his bladder wall had thickened as well. He is such a happy, healthy, cat now that I would recommend that she should at least talk to her vet about it. When it works, and the dosage has to be tinkered with a bit, it works wonders!