No experience w/Tramadol and pets, just that I'm switching to it myself b/c it's helping me w/my own pain. There are risks w/every drug we try but seeing that Metacam does damage the kidneys, the second vet is probably right on. I was concerned about giving it to my Boo but my vet assured me that it's ok for him but Boo isn't in CRF either. Just hold on tight and weigh your options, Slick. I found that I did so much reading that my mind just became clogged and I couldn't remember anything anyhow so I had to rely on my instincts, which were also shot by that time, so I know exactly how you feel. All you really have to do is love Max, then compare what the second vet said to what the first vet said. We're here for you. (((HUGS))) Keep the faythe.