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Thread: Canine Genetic Diseases - Please help me with my vet studies

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  1. #1
    Join Date
    Jan 2003
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    Kelowna, BC
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    12,062
    Hi Zara,

    I don't have any personal experiences with any of MY dogs, but I'm happy to share some experiences with other Belgian shepherds.

    As far as hip dysplasia goes, I think it's alot more common than anyone knows. I can sometimes tell just by looking at a dog if it's dysplastic -- but it's owner wouldn't even have a clue. Because it's so normal for dogs to be dysplastic, we assume that all dogs look and move this way. I think that if every single dog were to be x-rayed, most of them would be considered dysplastic (how many dogs have decent structure these days?? Poor structure can contribute to joint issues later on). Unfortunatly databases like OFA are not accurate because most people who have a dog x-rayed, only for the vet to tell them their dog is dysplastic, will not send in that x-ray to OFA. Not many breeders want that information on a public database (I'm not one of those breeders, I will gladly admit when I breed a health problem). Not only that, the extreme vast majority of the dogs x-rayed are purebred. This is one reason that people go on about "hybrid vigor." While some of it may remain true, the fact is that mutts don't generally get health tested or certified -- hence why OFA has a much larger amount of purebreds with hip dysplasia than mutts -- not because there is a higher incedence in purebreds.

    I think hip dysplasia is very intriguing, genetically. I'd really like to know more about how it works.
    Someone I know recently had a litter of Belgians. The dam comes from a long line of OFA excellent and good hips. However, her sire was never x-rayed. Well, turns out the sire has THREE siblings with hip dysplasia (even being out of a line with OFA good and excellent hips). When this bitch was x-rayed after her litter (it was an accidental litter before tests were done), the x-ray confirmed she is likely dysplastic (won't be sent in to OFA).
    This is a long line of health tested dogs going several generations back. One of my explanations for this is that while each dog in the pedigree may have had good hips -- it may have had siblings (that were never tested, or were tested and no results were sent in) with dysplasia. That dog could still carry those genetics.
    I know of a female Belgian with hip dysplasia that was bred. All of her tested pups had good or excellent hips. However, she had one great granddaughter that consistently produced hip dysplasia in all three of her litters. This is going down three generations of health tested hips after the dysplasia. If every single puppy in each of the dysplastic female's litters were tested, who knows how much dysplasia she actually produced? But only the breeding dogs were tested and found to have good hips, so her line continued (and does to this day).
    This is why it's part of my health guarantee that every owner is to certify hips, elbows, and eyes. Otherwise their entire health guarantee is void. I could happen to have the only OFA excellent puppy in the litter and breed it...but what if every single one of it's siblings is dysplastic? If they aren't tested, I won't know, and my OFA excellent dog could produce dysplasia.

    I think this is why dysplasia runs rampant in some breeds more than others. It is so genetically entwined, it is hard to get rid of. Not to mention, with the structure of some breeds these days (German shepherds for one) dogs are already predisposed to having issues. If a dog is overangulated in the rear, it's knees wear out, which causes hips to compensate, which causes hips to wear out. If GSDs were OFA'd at an age where this wear-out would naturally occur, as opposed to the usual 2 years that most people want it done by, I think we'd see alot more dysplastic x-rays. By the time the dog is that age, people blame it on age, not genetics. And these dogs have gone on to produce ten generations of dogs who have OFA excellent hips at 2 years of age, but would be considered dysplastic at 4 years of age.

    In my breed, the major problem is epilepsy. I find the majority of breeders just don't do enough to prevent it other than to make sure their own dogs don't have it. They breed to typey European show lines with seizure-producing dogs in the pedigree, and wonder why they end up with epilepsy. Seizures usually crop up between 3-4 years of age, but many times they will crop up in dogs as young as a year, and as old as 8 (some argue that dogs that develop seizures after age 7 do not have epilepsy, but rather a brain tumor -- no excuse to continue to breed a dog in my opinion). After 8 most people can be sure that their dog does not have epilepsy, but many Belgians will still develop thyroid problems which will cause seizures. Thyroid problems are seen much more commonly in other breeds, like goldens, but Belgians are much more prone to developing seizures from thyroid problems (or anything really -- seizures can pop up from any health problem a Belgian has, it seems). Most times seizures are just treated with the usual phenobarbital, but most Belgians will end up being PTS even with treatment. Some people estimate that epilepsy in Belgians is as high as 30%. Most breeders will not publicly admit when they produce epilepsy, and so we can't get an accurate estimate. But Belgian people are getting better and better about sharing health statistics publicly, and we're still working on finding the gene for epilepsy so we can eliminate it from the gene pool. Until then I'm using low-risk lines until I have no other options but to outcross to something new.

    I love talking about stuff like this, if I can think of anything else to talk about, I'll definatly post it. Another thing I'm interested in -- I find that lines where hip dysplasia pops up, also tend to see some elbow dysplasia. I wonder if there's a seperate gene that affects more than one joint? I've seen a few litters that come out of a line of health tested dogs... until the one litter pops up with a few hip dysplastic dogs and some elbow dysplastic dogs too. Always think that's interesting how both hips and elbows are affected.
    I've been BOO'd!

  2. #2
    Join Date
    Oct 2003
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    Sophia, NC (originally from SE OHIO)
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    394
    Quote Originally Posted by wolfsoul View Post
    Hi Zara,

    I don't have any personal experiences with any of MY dogs, but I'm happy to share some experiences with other Belgian shepherds.

    As far as hip dysplasia goes, I think it's alot more common than anyone knows. I can sometimes tell just by looking at a dog if it's dysplastic -- but it's owner wouldn't even have a clue. Because it's so normal for dogs to be dysplastic, we assume that all dogs look and move this way.
    I don't have much experience with this, as HD is fairly uncommon in Collies, however as far as noticing how dogs move. I have seen dogs, that ended up with bad HD (one being a Lab, one being a Spring) and they moved really well! I think it depends on the dog really. But I agree.. sometimes you can tell just by looking at how they move, that something isn't right.


    Quote Originally Posted by wolfsoul View Post
    I think that if every single dog were to be x-rayed, most of them would be considered dysplastic (how many dogs have decent structure these days?? Poor structure can contribute to joint issues later on). Unfortunatly databases like OFA are not accurate because most people who have a dog x-rayed, only for the vet to tell them their dog is dysplastic, will not send in that x-ray to OFA. Not many breeders want that information on a public database (I'm not one of those breeders, I will gladly admit when I breed a health problem). Not only that, the extreme vast majority of the dogs x-rayed are purebred. This is one reason that people go on about "hybrid vigor." While some of it may remain true, the fact is that mutts don't generally get health tested or certified -- hence why OFA has a much larger amount of purebreds with hip dysplasia than mutts -- not because there is a higher incedence in purebreds.
    Not sure I agree, that if all dogs were xrayed, most would be considered dysplastic, but I'm sure it would have a higher frequency. It just depends on what breed you are talking about. Of the dogs I've had OFA'd, most have been rated excellent and a couple have been good. But I do agree about mixed breeds and hybrid vigor, very few people do health tests and certify the dogs like purebreds, so its hard to tell for sure how frequent a problem is seen in mixed breeds, compared to purebreds.

    Luckily in my breed (Collies) hip dysplasia is not very common.
    However, the most commonly seen problem is CEA (collie eye anomaly), which affects about 77% of Collies world wide (and of the Collies that are "normal eyed" most are still carriers for the gene), but about 66% of those affected dogs have what is called Choroidal Hypoplasia, which is the mildest form of CEA, which does not get worse as they get older and it does not cause vision problems. About 8.75% have Coloboma's which is a small pit or bulged in the eye and about 1.8% have Retinal Detachment.

    Bloat is VERY common in some bloodlines.... lines I've tried to stay away from as much as possible. Dermatomyositis (commonly called DM in the Collie/sheltie world) is seen in some lines, though I've never personally seen a dog with it, just photos.
    If you're gonna breed Collies, don't you forget to breed in the brains and common sense. Without that you won't have a Collie, you'll have just another dog.



    I've Been BOO'd!!

  3. #3
    Join Date
    Jun 2001
    Location
    Glenside, pa
    Posts
    7,399
    Zara, My RB Cody, part yellow lab, part golden retreiver, was diagnosed with hip dysplasia before he was a year old. Logan, was 2 when I got her, but I noticed problems with her gait and movements soon afterwards, had her Xray'd, and it was determined her hips are awful. She takes glycosomine and an occassional 1/2 of Rimydal for discomfort.

    You'll do great on your exams and make an awesome vet!



    I've been Boooo'd!

  4. #4
    Join Date
    Jan 2003
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    Kelowna, BC
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    Quote Originally Posted by Spiritwind View Post

    Bloat is VERY common in some bloodlines.... lines I've tried to stay away from as much as possible. Dermatomyositis (commonly called DM in the Collie/sheltie world) is seen in some lines, though I've never personally seen a dog with it, just photos.
    Have you ever been to any Pat Hastings seminars? She believes that bloat is related to how short the sternum is or isn't. When you think about it, it makes sense -- the breeds most prone to bloat tend to be very short in the sternum (boxers, dobes, great danes, etc), allowing organs to be more exposed (including the stomach) than in a normal dog. It's one thing I feel for in dogs -- the sternum should be as close to the "belly button" as possible.

    In my grooming career, I have to say that almost all of the large breed dogs I groom I would consider dysplastic. Of course I also groom alot of breeds very prone to dysplasia genetically, but these are pet dogs that will never be x-rayed. And yes I agree it can be hard to tell by a dog's movement depeding on the dog. A good friend of mine has a sister who breeds pyrs -- everyone in the show ring always marveled at how well her dog moved -- just beautiful movement. When she had the dog x-rayed, it literally had no hip joints and no hip sockets to put joints in. It was one of the worst cases of dysplasia the vet had ever seen. Belgians are hard to tell by movement because they are light dogs, and they have a high pain threshold when they are working, so they will keep jumping and running as long as you tell them to. I think alot of times it can depend on the breed involved.
    I've been BOO'd!

  5. #5
    My RB Mandy had SAS-Sub Aortic Stenosis. She was a Lab/Golden mix. She was diagnosed at three months. She had a grade 5-6 murmur. The Vets at Ohio State U. put her on atenolol. The surgeries don't prove to prolong the dogs life and they felt she was so bad she would not survive the surgery. She lived just past five years old. Infection took her life in the form of Pyrometra. All we could try was antibiotics as she would not have been able to handle the other treatments. We didn't have her spayed due to the higher risk with that surgery.
    Zara, if you're interested, just ask for more info and good luck.
    Here's a link about SAS...
    http://www.marvistavet.com/html/subaortic_stenosis.html
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    Forever in my heart...
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  6. #6
    Join Date
    Sep 2005
    Location
    At university in Hertfordshire, UK
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    4,944
    Wow, thanks so much everyone, this is a brilliant help.

    Elbow dysplasia is something I've not seen too much of either. I have seen a luxation of the elbow joint in a labrador cross, but I don't think it's quite the same. Correct me if I'm wrong there.

    I would also assume that hip and elbow conditions would go hand in hand, as if weight distribution is affecting the hind limbs then it seems likely that the forelimbs will be experiencing similar problems.

    Quote Originally Posted by Spiritwind
    However, the most commonly seen problem is CEA (collie eye anomaly), which affects about 77% of Collies world wide (and of the Collies that are "normal eyed" most are still carriers for the gene), but about 66% of those affected dogs have what is called Choroidal Hypoplasia, which is the mildest form of CEA, which does not get worse as they get older and it does not cause vision problems. About 8.75% have Coloboma's which is a small pit or bulged in the eye and about 1.8% have Retinal Detachment.
    I have read a little about CH, this is the condition, I think, where the tissues between the retina and sclera don't form properly? I've never come across CEA before though. I have seen two cases of colobomas before, one fairly serious and the other not quite so.

    Karen, I'm so sorry to hear about Logan's hips, poor girl. This may sound silly, but what exactly about her gait did you notice? Not having come across the condition a lot and not having owned a dog before, I'm a little green when it comes to spotting these things.

    Also the point about the length of sternum is very interesting, I'll have to research that a bit further. I'd only ever really thought about the cranium, spine and joints being the areas of skeletal disorders before.

    Quote Originally Posted by chocolatepuppy
    My RB Mandy had SAS-Sub Aortic Stenosis. She was a Lab/Golden mix. She was diagnosed at three months. She had a grade 5-6 murmur. The Vets at Ohio State U. put her on atenolol. The surgeries don't prove to prolong the dogs life and they felt she was so bad she would not survive the surgery. She lived just past five years old. Infection took her life in the form of Pyrometra. All we could try was antibiotics as she would not have been able to handle the other treatments. We didn't have her spayed due to the higher risk with that surgery.
    Zara, if you're interested, just ask for more info and good luck.
    Here's a link about SAS...
    http://www.marvistavet.com/html/subaortic_stenosis.html
    Thanks for the link, and I'm so sorry that sweet Mandy had this condition. This is also a condition I've remotely heard of but not really experienced. So the narrowing of the aorta (I think stenosis is to do with narrowing?) brings on the murmur? The only murmurs I have ever encountered were to do with leaky valves.

    The conditions I've come across most often are in the short-nosed breeds; cleft palates, elongated soft palates and bronchial or tracheal collapse. I also recently witnessed a bulldog caesarian (I'm under the impression that a lot of bulldogs can no longer give birth naturlly due to the breed standards demand for such huge heads) and it was so disheartening when two puppies were born cleft and the breeder requested their destruction. Such a waste.

    Does anyone have any further knowledge on these conditions?

    Zimbabwe 07/13


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