One of my cats is on amitryptiline and he has no more peeing problems. You can't skip a day, believe me. He has gotten to the point where he expects the pill every night and is quite nice about it. He used to attack me until I bled, but I persisted and now he is so much better. He no longer pees out of the box or gets obstructed. So try meds, they can help sooo much.