Yes, I would be very careful about cleaning his wrinkles, maybe make a habit of it every day after he eats his dinner, as bulldogs often have that problem, and the flat face, along with those deep wrinkles, means stuff, as well as sweat, can tend to get in there. Making cleaning his wrinkles part of his routine, and making a big fuss over him as you clean (bulldogs being absolute suckers for attention, I know!) may help clear this up and [revent problems in the future. Stainless or ceramic dishes may help, too.