You mentioned that you've tried Prozac and Ametryptilene but have you tried Clomicalm? Forgive me if I suggested this previously but I've had such good success w/it w/no side effects in any of my cats. They each get 1/4 of a 20 mg. pill at night before bed and there have been no pee incidents since. The key is to be consistent (don't miss a dose) and to give it to them before bed. It keeps them calm so that they sleep well but it doesn't drug them and it has a slight residual effect so that they behave during the day. It's been a godsend for this household. Some vets say that it takes a while to work but it began working immediately for my cats. Some people have a generic liquid compounded or a generic capsule made because they're less expensive but they also have not seen as much success w/it. I bit the bullet and bought the pills and no more inappropriate peeing. It costs $34 for a one month supply and it's worth every penny. Why not talk to your vet about it? It'll save your house and your sanity. Good luck. I know how frustrating and embarrassing it can be. I had 4 out of control cats until I started them on Clomicalm.