Wow! When I was having some issues, I was lucky in that I knew it was only 2 of my cats so I just brought them in to the vets. My vet sticks a needle into their bladder to get urine so I don't have to go through the experience of collecting urine samples. I would also think that diet would play a big role in the high PH and the crystal problem. I hope that the meds will help everyone. Good luck and please continue to keep us updated.