I used amitryptilene on my Specs because he was spraying and attacking Boo every day. In the beginning it worked but not for long. Then my vet suggested Buspar. Nothing. So he tried Clomicalm and voila! I have 4 of my cats w/bad manners on it and I've had no spraying incidents or attacks since then. I'd say to give amitryptilene a good try; it may work for you. If not, Clomicalm is wonderful. And Prozac is getting rave reviews for just this very thing. Take heart; better days are coming.......