I sure hope the Clomicalm works for you because I've had so much success w/it. I've not tried Prozac although I know some PTers have. Before Clomicalm, I had them on valium and buspar w/no success at all. I was ready to boot Specs out the window because he actually ruined my dining room server, warped the wood so badly that I couldn't close the door, so you can imagine the smell, too. When I bought his house a couple of years ago, I gradually bought all new furniture, the dining room being my prized room. No way am I going to allow these cats, as much as I love them and would do anything for them, to make my house their own private litter box. I hate the thought of them being on medication but if that's what it takes, that's what it takes. Good luck and keep us posted.