I know I probably sound like a commercial but give Clomicalm a try. I've got some pee cats and it works really well. I thought maybe I'd take them off it to see if it would make a difference. Oh yeah! Next day, pee! Back on the Clomicalm. I've noticed the biggest change in Coco Puff. He's a cerebellar hypoplasia kitty and after nearly two year of living here, he's decided to start spraying. I put him on it and he calmed right down. It doesn't make them drowsy or change their personalities or anything negative. I feel I need to make a disclaimer here and say that, of course, all cats are different just as humans are, and medication affects them differently. But talk it over w/your vet and see what s/he says. It's been a godsend to me and it's inexpensive. It's priced around $30 or so for a 30 day supply. My vet gives me 20 mg. tablets and they get 1/4 tablet at night at bedtime. So if you have only one cat that's peeing, then you'll get 4 times the amount of medication. See what your vet says but it's made a big difference around here. Good luck.