I agree with all the recommendations about taking them to the vet. Talk to them about which de-worming medicine to use. They will probably look at a stool sample and find out what parasites are in the pups and give you a medication that will take care of all of them. I use one that also includes heartworm preventative medication and is given monthly. Depending on what parasites are common in your area, different medications will be more suited to your pups. I do not recommend going to your local big-box store (aka WalMart) and buying over the counter products, since they are usually much less effective in general. I tried this first, not knowing any better, and it did absolutely nothing for my dogs, and I followed the box directions exactly.