My rats have had lice -- in fact, I just got rid of some last week.I use coconut an peppermint shampoo on them everyday to get rid of lice. It isn't as effective as pesticide shampoo, but it's chemical-free. I freeze and wash their bedding and keep their cage as clean as possible. I also make sure to give them Nutri-Cal to boost their immune systems so their bodies can fight the lice off. Poor Oliver gets the nutrition sucked right out of him when he gets lice.