I swear by yukky Cold-Eze at the very first symptom. I also gargle with Listerine and spray my nose with Saline solution, and take extra stength Tylonel.. Knock on Wood, I haven't had a full fledged cold in decades. I'm not a fanatic, but I do try to remember to wash my hands with antibacterial soap and not touch my face after I go out, like food shopping or to the mall.