well, being that my cat Shy was abused as a kitten, i can tell you whatever the problem your cat has it will take alot of patience and understanding on your part...if she is resisting being picked up, don't pick her up...identify the things that stress her and then try to eliminate or minimize that situation...give her time...let guests know that she has special needs and not to handle her, just let her do her own thing...do not be worried though, because with patience, understanding, and love she will come around...btw Shy is almost 11 years old and i still canot pick her up...(10 sec is most)...good luck...keep us posted and welcome to PT!!!!!!!!!!!!!!!

tim