Hi krazyaboutkatz and Pepper! This is a link to an excellent vet info. site. In the Cat section...Megacolon.....lots of info. about different treatments is offered. This vet seems confident in recommending surgery as a safe alternative when medications are not working. Have you seen a specialist? I would defintiely talk it over with your vet. This is a chronic problem, and, if you are not having success with medications, definitely talk it over with your her of him! Love and hugs to dear Pepper. Keep us updated, ok??? Sandra

Here's the link...Make sure you scroll up to the top of the page!

http://www.vetinfo.com/cmegacol.html#Megacolon