I had to pill Taz by myself. I got the pill shooter from the vet. I got on the floor and wedged him between my legs (or just to the side of me). Open his mouth and shoot the pill as far back as possible. Close his mouth, rub his throat and his nose lightly so he'll lick it then he has to swallow.
It was a bit of a pain and I only failed twice. Once he spit the pill back out and it became too slimy to use. Another he actually bit the pill in half.

As others said - each cat and person is different. So you've got multiple suggestions you can try until you find the right one for you and the girls.