To be honest, Clomicalm is to reduce stress (correct?). This does not sound like stress. To me it is either she CANNOT make it to a box or she DOESN'T CARE IF she makes it to a box. Unless she has been a problem pee-er in the past, I would doubt if this is caused by attitude.
For the record, if this is your breaking point, it is legitimate. People, no matter how noble, can only handle so much. You have to honestly ask yourself how much can you take?
I think she's just plain miserable
If she IS miserable, I think you KNOW what you have to do.

I apologize if any of this sounds harsh or heartless, but it is not meant to be. It is life...............

Hugs and prayers are with you now, more than ever.