They won't remember pottying in the house, but they will smell where they used to go. Simple Solution or Nature's Miracle are great! FYI - the carpet cleaner actually doesn't have any enzymes in it to fight odor. The ingredients in at are actually the same as most other carpet cleaners. Fooled me once, but I returned it after I compared it to the bottle of regular cleaner I had at home. The odor & stain remover they sell does work really well, though. You have to SOAK the carpet for it to work.