YLL a link or links if I find more about Ehtoxyquin effecting rats...very scary stuff!

rats


"Ethoxyquin has low oral toxicity in test animals. The oral LD50 of 20% and 50%, ethoxyquin in rats is 800-1,000mg/kg and the oral LD50 for 70% ethoxyquin in rats is 3,300 mg/kg. The oral LD50s in mice for 0.125% and 0.25% ethoxyquin are 85.7 -94.0 mg/kg and 98.5-112.1 mg/kg, respectively. This compound is a mild skin and eye irritant in test animals. Ethoxyquin was found to significantly decrease body weight, food intake, and occasionally growth rate in rats, cows, dogs, chickens, and mice exposed to prechronic and chronic doses in animal feed. In these studies, ethoxyquin caused a significant increase in liver and kidney weights in test animals. In male rats, adverse effects observed included scars on kidneys, inclusions in hepatic cells, and kidney lesions in the higher dosed groups (500-4000 ppm). Effects characteristic of chronic glomerulus nephrosis in male rats exposed to 4,000 ppm ethoxyquin were observed. In dogs fed doses of ethoxyquin ranging from 10-100 mg/kg, adverse effects observed included anorexia, abdominal pain, and increased liver and kidney weights. Dose-dependent exogenous pigment was seen in all groups. These animals also exhibited an increased fat content in the collecting tubules of kidneys, suggestive of fatty nephrosis. Limited data were found on the carcinogenic potential ofethoxyquin. This chemical has been found to be a weak bladder carcinogen in rats."