When we took our 9 cats to Cape Cod(a 6-8 hour ride depending on the traffic), the cats did not eat breakfast the morning of the trip. They were all in their own carrier. Spunky was the only one that got car sick. I use to give him Ginger and a homeopathic remedy(I cannot recall now. Will look it up and post again). A few trips, I put the harness and leash on Spunky, and put a towel on my lap, and let Spunky sleep on my lap. He was not allowed to roam the mini-van. I also had a litterbox available, just in case Spunky needed to use the box(and he did). Never had to use drugs...Good luck and happy travels!!!