I agree, awesome suggestions Catlady711!!!!
An infection really does need to be ruled out before anything else.
Above and beyond that, Feliway might help calm her a bit. It is a synthetic pheronome that deals with anxiety and inappropriate urination. You can get it in a spray or in a plug in (like glade plug-in but pheronomes instead). There is a cheaper version of it available at the larger petstores.

You mentioned that you have other animals. Are any of them cats? She might do well with a feline companion to keep her company.

I find that leaving the tv on in our bedroom for our cats during the day keeps them content. They seem calmer with some background sounds going.

But, as Catlady711 said, she should be checked by a vet to rule out anything medical that could be treated. It would be awful if she was uncomfortable or worse, in pain with an infection of some kind.