Yikes! This is so timely as my GR mix Cody has been on a twice daily dose of Rimydal for about a month. The vet did take blood tests before prescribing it, and I was advised to get blood work done every 3 months. He has hip dysplasia and has developed arthritis in his knees from ACL surgery years ago. The vet said he was very healthy otherwise and since he'll be 11 yrs old, to make him comfortable at this point in his life.. I knew aout the liver damage so I'm scared to death and keep a watchful eye on his body functions. Thanks all for the descriptive warnings. I would never fo anything to harm Cody, of course, but the sight of him sometimes struggling or limping just tears me to pieces. I take arthritis drugs myself and pray for the best, and get bloodwork. I am so very sorry and sad to read about Penny. My heart goes out to you. I just perish the thought and can't pretend to imagine what you went through. Poor baby. You have my sincere condolences.