My rescue group does something called a "calendar raffle" where each day of a month there's a dollar prize, which varies from $50 to $400. We have cleaned up with these. In fact, we are going from 2 to 3 a year by popular demand.

Our other large fundraiser is a penny social. We hit up merchants for donations, gift certificates, etc. Also people donate brand new items that they may have gotten as gifts but don't like. We have a 50/50 raffle table, and tables for larger prizes (bonus, super bonus) and a "basket of cheer" table.

We run a Christmas newsletter which often does quite well.

We have tag sales about every 2 months.

We are starting to apply for grants, but need to get better organized with paperwork.

We also have coin cans, and a booth at the local cat show where we can raffle stuff off. We usually do pretty well.

My pet project is to set up an antiques appraisal fair/silent auction where antique dealers pay to have a table, donate items for the silent auction, and get a few appraisers to appraise small items for a fee.

It sounds like you might have a higher budget than my organization. PM me if you want any figures or advice on logistics.