Depends... they need a rabies vac. by law. Other than that, its personal preference. I updated al my guys, simply because of all the fosters that mingle with them. If I didn't foster, I might think twice about the basic shots because they are not outside to become exposed to the illness. Even one of the head honchoes with the rescue does not vaccinate her cats except for rabies (though we will use it as a reason for not adopting a cat to someone who we have "iffy" feelings about)