I was going to suggest the same thing Jen did. I had to play around with Magoo's meds until I got the right dosage and it sounds like Ripley is getting too much. You might want to start of a with quarter of a pill and work your way up until you find the right amount for him. Poor thing shouldn't have to be that affected.
I know Magoo seemed more paranoid until I got his dosage right. He was super nervous instead of calm and he would constantly be on the move as if he were trying to walk it off or maybe even afraid to lay down and give in to it. I'm sure they get confused when their head doesn't feel right and they can't understand it.
Good luck Ripley and Lori. Keep us posted.