It is VERY bitter! I wrap it in a small piece of a Pill Pocket, they sell them at Pet Smart. After a year, Ming just opens his mouth and takes the pill without much trouble. It takes two of us, but it is done without much trouble. The first few weeks, until I discovered the Pill Pocket trick, was very hard. Ming won't eat the pill in the Pill Pocket on his own, the pills are that bitter, but you can ask you vet for a pill popper to shoot the pill down his throat, or just get behind him, lift his head up a little, and place the pill at the very back of his throat. He should then swallow as a reflex. Sometimes I have to almost shove the pill down his throat with my finger. As long as you are doing this from behing the cat, you can't be bitten. Your vet tech can show you how to do this.