So sorry to hear that both kitties no longer want to play together. Could it be that two females just are not working out together? I do realize that Iris thinks Iza is a stranger in Iris's home, so maybe that's it. Don't worry, I just adopted a new kitty too, and while my original kitty does not want him messing with her, they will sleep on the same bed and touch noses, so maybe there is hope for both our situations. Take care, and just keep loving your kids!