Cats usually urinate outside the box because they are upset about something. (If they are healthy, otherwise)

Have you tried addind Rescue Remedy to her water? You can get it at GNC. Its a natural calmer. They also sell something at Petco and PetSmart called Comfort Zone. They have plug ins and a spray. This is a pharamone cats exude when they are calm. They work pretty well.

Your kitty probably just needs time and extra love. That is a lot of change to go through for an animal. They don't understand change.

Hope that helps.