I hope your trip is a smooth one . The main thing I would suggest is taking her on a lot of shorter car rides before the big one, make sure she's used to it and that the car isn't a scary place for her. Tasha used to get car sick when she was a pup, but I think some of it was nerves, it was scary for her. After lots more car rides (with an empty stomach ), she seemed to get better. While she still isn't super thrilled about the actual ride, she loves the excitement of going somewhere. When we stop, she starts crying and shivering in excitement, wanting to get out and explore. She hops right in when the door opens, ready to go.