As far as ticks go, we don't usually see a problemw with them unless we are out frolicing in the woods. As for the fleas though...Frontline helps a lot, but not a total cure for Chloe. I have to keep it on her more often than once a month...usually every 3 weeks. I still see the ocassional flea, even with the increased use, and she still scratches uncontrollably. She does have very sensitive skin and is allergic to so much...so in that respect, both Frontline and low doses of children's benadryl (sp?) help. Anyone else have a really itchy pup??