I do brush my cats' teeth weekly and clip their nails. I first grab them one at a time and put them into a cut off sweat shirt sleeve allowing their little head to stick out leaving their claws and paws within the sleeve. They also get pills this way, when necessary, of course. The sweat shirt sleeve is very, very thick.... and soft and confines them just enough so that they have room to wiggle, but because their fat heads are at the cuff end, they can't escape! Works every time. Sometimes they run when they see the sleeve, but I leave it out all the time...so they never know when they will be "wearing" it! Hope this helps! =^..^=