Kim, I just took in a mom cat and her two kittens last week (The Dairy Queen) and they were seething with fleas as well. I put one drop of Advantage on the kittens, and an adult dose on the mom cat. Many shelters (including the one that had been nearby for 30 something years, and closed doors with little warning) apply Advantage to tiny ones, but never any more than one drop. I've had no problems doing this, and it beats having a flea infestation, and anemic kittens. It must be incredibly frustrating to not have any support from area shelters. It makes it so hard to adopt out this avalanche of kittens!