I too have a G4 with OSX panther and we have a HP printer, but it's not a scanner, just a printer. We've had no problems with it working with the G4 or with my husbands G5 powerbook. We had problems with our old printer/scanner (I don't remember what it was, but not HP) working with the mac and that's why we got this one. I'm sorry, but I really can't help you, I'll ask my husband when he gets home, he may know better how to help you.