I've never tried it on my cats before, but I know there is one cat I take care of on a regular basis and it has helped her so much. She used to not get anywhere near me when I would go in, and once they started giving her the rescue remedy she started to actually ask for my attention. She also used to run away from her food dish if I even made the smallest noise, but now she will happily eat while I walk around the house doing the rest of the chores.