yes i had to give my kitties sedatives when i moved them severl hours away from home, but the vet gave me tablets called atravet, there where no side effects other than the cats being very lethargec..... ok they looked drunk, but where fine by the time we got the to the destination..... ask your vet or check the shelves...that was in canada, so i don't know what they would have here! i know you frustration, my male once pulled a tooth out biting at the bars of his crate! Good luck!