We've never been on vacation since we've had Ori and Wilber. Or on the very rare occassion one of us had to leave town, the other had to stay home. When we go on our honeymoon, I'll have my stepmom come take care of them. She is a pet nanny and is trustworthy. Their will be a couple of days when she will be with us for the wedding, so I've asked her to let me know which Pet Nanny at her company she trusts most and we will have them look in on the guys. I would never board them unless there was NO other option. We boarded them overnight when we moved. That, in my eyes was the lesser of two evils, risk having them run out the door, or have them be very unhappy overnight in a 'pet hotel'?