Cats with chronic conditions often learn to accept their medicine. We had a foster who had hyperthyroid, and all the volunteers were able to pill her no problem. I think the choice of treatment depends on the cat's age, and the purrent's pocketbook and willingness to have the cat in quarantine, etc.

I wonder why the cat needs to be isolated like that. I had I131 and only couldn't kiss, etc. my mate for a week. Maybe it's because cats lick each other.