DES a female hormone which fell out of favor in the early 60's in human medicine. The theory being is that if a female dog is spayed before the tissues have a chance to generate then there is not enough pressure on the urethra to keep it from dribbling out. The DES causes the surrounding tissues to swell, thereby giving better muscle control.

Back to Buddy... The most frequent cause of incontinence in older dogs is urinary track infection which might include the begining of a kidney infection. A check of a urine sample by the Vet can confirm. Unless your male dog has experienced this all of his life, it's unlikely to be hormone related. Other causes could be kidney stones being passed irritating the track, or metabolic disease such as diabetes or cushings (e.g. Has your dog been consuming more water recently?). You may have to go through some diagnostics to get at the root cause.