One of my elderly cats (RB) Bear went totally blind towards the end. Now realize that he already KNEW the house, but he did very well. He could take the stairs both up and down. he never missed the litter pan and he knew where to find food and water. He lived at least 1 year after his sight went.
If you can get him used to a small area then I see no reason it ould not work (but don't move things around.......keep everything in the same place)
That's All I can say except good luck and thanks.