Oddly enough, as unbelievably terroristic as Ritz is at the vets, we have never had trouble medicating. She lets us pry her mouth open and squirt it in...there was one medication that tasted awful that made her make a lot of faces and head shakes after, but she has been a good kitty...

My spouse usually sits on the floor, gets Ritz to come and sit between his legs--he pets and reassures her, then takes her head in one hand and gently coaxes her head up, and pries her jaw open, then SQUIRT with the other hand ---then pets and praises her.

I'm always amazed at how malleable she is for us - I know the vets couldn't do this to her if they wanted to, they won't even check her teeth during regular checkups unless they sedate.