Two of my six have thyroid problems and are on meds twice a day. Symptoms very similar to Glaciers, especially the fur problems with Thunder, the male. Also both were rather grouchy (again, especially the male) and just not happy. The thyroid meds are working miracles. Good luck this may just be the answer. Don't know about the un-tested drugs though, espcially when vet recommended drugs are working so well for me. It makes me feel so good to see a happy look on their faces