It does sound like she is going through some sort of depression.
My husband had the whole thing, depression, anxiety/panic attacks, for a very long time, he did not go anywhere, he stayed home all the time. It was such a hardship on the whole family. Getting treatment helps, but as somebody said, she may need to change medications, the zoloft may not be working anymore. It is pure hell for the whole family. We were afraid to even open our mouth in front of him, or he would start yelling at us. It got really bad.

Now I have went through it so long with him, about 15 years of it along with his other health problems, I am now suffering from depression too. I don't like going anywhere either, I will go sometimes, but strictly because I have to go or somebody makes me go. I hate it, it is terrible.

I am sorry that you are going through this, everyone in the family are going through this, it affects the whole family.

sorry