Have you/she considered that she might be agorophobic? People who are agorophobic do not like leaving their home, though it varies from person to person, but some only feel safe in a certain room, while others are fine as long as they are indoors. She can still be depressed even if she's takingmedication - anti-depressives work differently for different people, and the dose or medication may have to be adjusted.
In any case, I am sending you a great big hug. I was lucky to have a great mom, I thought everyone did until I grew up and realized how rare it is. Were she still alive, I'd lend her to you - Ma always took in strays. At her funeral, one woman drove for 6 hours just to attend, one man came without a baseball cap on in respect for her, and his wife said it was the only time she'd ever seen him in public without one. Both were other people's kids who bunked at our house from time to time.
Try thinking of her not as your mother, but maybe as some other relative ... an Aunt or something. That's what my friend does, and said it made it a lot easier - you expect less, so are dissappointed less ...
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